The suppressive effect of the three-herb extract mixture on vascular and liver inflammation in atherogenic diet with high fructose-fed mice

The suppressive effect of the three-herb extract mixture on vascular and liver inflammation in atherogenic diet with high fructose-fed mice

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Context: Cynanchum wilfordii (Maximowicz) Hemsley (Apocynaceae), Arctium lappa L.var.rubescens Frivald (Asteraceae) and Dioscorea opposite Thunb (Dioscoreaceae) root extracts have been widely used as an alternative for intervening obesity.

Objectives: The synergistic effect bostik universal primer pro of three-herb mixture of C.wilfordii, A.lappa and D.

opposita was determined on aortic and liver inflammatory responses.Materials and methods: CWE, ALE and DOE were prepared from the root of C.wilfordii, A.

lappa and D.opposite by 70% ethanol extraction, respectively.CADE was prepared using a powder mixture of 2 CWE:1 ALE:1 DOE.

C57BL/6 mice were fed an atherogenic diet combined with 10% fructose (ATHFR) in the presence of 200 mg/kg/day CWE, ALE, DOE or CADE for 8 weeks (each group, n = 6).Biochemical profiles, protein expression of vascular cell adhesion molecule-1 (VCAM-1) on the aorta and liver were determined.Results: CADE could significantly suppress the protein expression of VCAM-1 in both the aorta and liver (80% reduction) compared to read more ATHFR-fed mice.

Impairment of liver function was significantly ameliorated by CADE supplement, as determined by GOT (60% reduction) and GPT (51% reduction) levels.Conclusions: CADE should be considered when developing medications to suppress the vascular and liver inflammatory responses for individuals who are either non-responsive or resistant to lipid-lowering drugs.